glioma
Conditions
Interventions
experimental group :endostar plus chemoradiotherapy
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. KPS score (>=60); 3. Patients with glioma (WHO III-IV grade) confirmed by medical history or pathological examination who finished total resection, partial resection or biopsy; 4. Leukocyte count (>4.0 *10^9/L) and platelet count (>100 *10^9/L). 5. Blood urea nitrogen and creatinine < 1.5 times value of the upper limit of normal laboratory. 6. Blood total bilirubin and direct bilirubin <1.5 times value of the upper limit of normal laboratory. 7. ALT and AST < 1.5 times value of the upper limit of normal laboratory. 8. Persons who were previously healthy and had no serious allergic reaction to biological agents; 9. Patients voluntarily participate in the group, good compliance, can cooperate with the experimental observation, and Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe compression of brainstem, hydrocephalus and other nervous system diseases, which need urgent treatment; 2. Patients with acute or chronic infectious diseases or infectious diseases; 3. Patients with heart disease, cardiac insufficiency or abnormal electrocardiogram; 4. Patients with uncontrollable mental illness, mental disorder and poor compliance; 5. Patients who hemorrhaged recently; 6. Patients who also participated in other clinical trials; 7. Patients who should not participate in the trial judged by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival;objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;safety; | — |
Countries
China
Contacts
Public ContactPengfei Sun
Lanzhou University Second Hospital
Outcome results
None listed