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Study on the correlation between IBS-D and UC damp-heat syndrome and intestinal flora based on LPDC immune activation and the intervention effect of Gegen Qinlian Decoction

Study on the correlation between IBS-D and UC damp-heat syndrome and intestinal flora based on LPDC immune activation and the intervention effect of Gegen Qinlian Decoction

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900025627
Enrollment
Unknown
Registered
2019-09-03
Start date
2019-09-20
Completion date
Unknown
Last updated
2019-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative Colitis

Interventions

Sponsors

The Second Affiliated Hospital of Guangzhou University of TCM
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Complying with the diagnostic criteria of IBS-D damp-heat syndrome and UC (left colon type, active stage, mild) damp-heat syndrome. It is necessary to judge the yellow and greasy tongue coating of damp-heat syndrome. 2) Aged between 18 and 70 years; 3) No probiotics such as antibiotics, steroids, Chinese herbal preparations (including oral and intravenous injection), microecological preparations or yogurt were taken in the past week. 4) The patient signed the informed consent and was willing to receive the corresponding examination and treatment.

Exclusion criteria

Exclusion criteria: 1) Patients with severe heart, liver, kidney and other major organ diseases, hematopoietic system, nervous system or psychiatric diseases; 2) Complicated with other organic diseases of digestive system (such as peptic ulcer), or systemic diseases (such as hyperthyroidism and diabetes) that affect digestive tract motility; 3) Those who are or need to continue to use drugs that may affect gastrointestinal function (anti-diarrhea, anti-depressants, anti-anxiety drugs, intestinal flora regulators, antibiotics, etc.); 4) Allergic allergy history and severe food allergy history used in all research institutes; 5) Mental illness and mental and language disorders; 6) Pregnant or pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
IBS symptom severity scal;IBS quality of life, IBS-QOL;Defecation symptoms, abdominal pain, abdominal distension;Before and after the treatment Hamilton Anxiety Scale;Before and after the treatment Hamilton Depression Scale;Modified Mayo activity index;IBD quality of life;TCM syndrome;Endoscopic intestinal mucosal score;

Countries

China

Contacts

Public ContactHuang Shaogang

The Second Affiliated Hospital of Guangzhou University of TCM

huangshaogang@126.com+86 13926451320

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026