Early-onset schizophrenia
Conditions
Interventions
early-onset schizophrenia:Standardized antipsychotic treatment for 12 weeks
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
7 Years to 18 Years
Inclusion criteria
Inclusion criteria: EOS: The Han nationality aged 7 to 18 years old; First-Episode Patients without treatment, or nearly 3 months without using of antipsychotic treatment in patients with early-onset schizophrenia; using the standardized DSM-IV-TR axis I disorder stereotyping clinical examination (SCID) as a screening tool and forming the DSM-? diagnosis criteria for schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Forth edition, American Psychiatric Association); patients with consistent diagnosis who are independent diagnosed by two attending or above-level physicians respectively; positive and negative symptoms scale (PANSS) score >=70; patients and their families agree to participate in this study. Healthy control: Agreeing to participate in this study and signing the informed consent;the han nationality; more than 7 and less than 18 years old; no mental disorder diagnosised by the standardized DSM-IV-TR axis I disorder stereotyping clinical examination (SCID); no mental disorder or hereditary nervous system disease in two families and three generations of relatives; matched with the patient group according to age, sex and years of education.
Exclusion criteria
Exclusion criteria: EOS: Pregnant or lactating women;history of head injury and major body disease;with other neural psychiatric disorders;receiving modified electric convulsive therapy(MECT), therapy of antipsychotic or antidepressants in 6 months. Healthy control: History of brain organic diseases or other clinically significant physical illness; history of head injury and loss of consciousness for more than 30 minutes;abuse of alcohol or dependence of other substances; having participated in other drug clinical trials within 30 days; obvious abnormal laboratory results (except for liver and kidney function, the results of laboratory examination are more 1.5 times than the normal value).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical information;Cognitive data; | — |
Countries
China
Contacts
Public ContactSha Liu
The First Hospital of Shanxi Medical University
Outcome results
None listed