Effects of Lactobacillus reuteri DSM 17938 in Preterm Infants: A double-blinded randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025590

Enrollment

Unknown

Registered

2019-09-02

Start date

2019-10-01

Completion date

Unknown

Last updated

2019-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

feeding tolerance, growth, and infection prevention in preterm infants

Interventions

Experimental group:the intervention group was given a dose of 1×108 colony-forming units (5 drops) of L. reuteri DSM 17938 once daily, beginning with the first feeding until discharge

control group:The control group did not receive probiotics

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: formula-fed preterm infants admitted within 12 hours of birth whose gestational age 30 to 37 weeks; birthweight >= 1500 g and <=2000 g with vital sign and hemodynamic parameters stable.

Exclusion criteria

Exclusion criteria: congenital diseases, expected hospitalization less than 2 weeks and maternal or neonatal antibiotics or other probiotics before admission.

Design outcomes

Primary

Measure	Time frame
Reflux (times/d);time to full enteral feedings;Weight gain (g/d);head circumference increase (cm/d);Body length increase (cm/d);	—

Secondary

Measure	Time frame
Sepsis;Localized infection;NEC;Defecation (times/d);Hospital stay (d);	—

Countries

China

Contacts

Public ContactJianhua Fu

Shengjing Hospital, China Medical University

liying58522@163.com+86 18940251830

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 1, 2026