cricopharyngeal dysfunction
Conditions
Interventions
BOTOX group:BOTOX injection
control group:Normal saline
Sponsors
The Third Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Men and women meeting the diagnostic criteria of stroke listed in the 4th national cerebrovascular academic conference; 2) stable vital signs without severe cardiopulmonary disease; 3) aged 18~90 years; 4) no significant improvement in swallowing function after 1 week of balloon dilation; 5) functional oral intake scale (FOIS) 20mmHg; 8) good cooperation; 9) signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) patient with other neurogenic dysphagia or disease which can cause dysphagia; 2) patient with non-neurogenic dysphagia (e.g. cancer); 3) patient with neurogenic disease (e.g. myasthenia gravis, motor neuron disease); 4) patient with progressive psychopathy; 5) patient can't cooperate examination and treatment; 6) infections and cuts at injection site; 7) patient allergic to botulinum toxin; 8) patient with coagulation dysfunction; 9) patient used the medicine worked on the neuromuscular junction or anesthetics within 1 month; 10) patient joined other study which could influence the results of the injection of botulinum toxin on cricopharyngeal muscle.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Oral Intake Scale (FOIS); | — |
Secondary
| Measure | Time frame |
|---|---|
| relaxation residual pressure of UES;resting pressure of UES;relaxation duration of UES;velopharyngeal and laryngopharyngeal peak pressure;Degree, range and time of cyclopharyngeal muscle opening;pharyngeal construction ratio;Residual in epiglottis valley or piriform sinus;penetration and aspiration; | — |
Countries
China
Contacts
Public ContactWen Hongmei
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed