hypothyroxinemia in pregnancy
Conditions
Interventions
control group:L-T4 25µg
experimental group:Dynamic adjustment of L-T4 dosage and duration according to thyroid function at different stages of pregnancy.
Sponsors
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
Eligibility
Sex/Gender
Female
Age
19 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Pregnant women of the First Trimester in The First Maternity and Infant Hospital,Punan Hospital,Beicai Community Health Center. 2) Between the ages of 19 years and 40 years. 3) Less than 8 weekgestation. 4) Signleton pregnancy. 5) Normal TSH (0.06-3.83mIU/l) in the first trimester.
Exclusion criteria
Exclusion criteria: 1) History of thyroid diseases; 2) Taking medication effecting the function of thyroid before pregnancy; 3) Enlargement of thyroid gland; 4) Other autoimmunity diseases (systemic lupus erythematosus, undifferentiated connective tissue disease, antiphospholipid syndrome); 5) Infertiliyt,recurrent abortion or pregnancy after artificial insemination or IVE-ET; 6) Chronic diseases:hypertension,diabetes mellitus; 7) Medications except folic acid or compound vitamins, such as anticoagulants, glucocorticoids or other relevant treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure in pregnancy;size of fetus;weight of newborn; | — |
Countries
China
Contacts
Public ContactDu Qiaoling
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
Outcome results
None listed