Gastric Cancer
Conditions
Interventions
Total gastrectomy:Total gastrectomy
Proximal gastrectomy :Proximal gastrectomy
Sponsors
Jiangsu Cancer Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years, male or female; 2. Be diagnosed as adenocarcinoma by endoscopic biopsy; 3. The tumor is located in the the upper third of the stomach(including the esophagogastric junction), the long diameter =90g / L; white blood cell count (WBC)>= normal limit; neutrophil absolute value (ANC) >=1.5 x 10^9 / L; platelet count >= 100x 10^9 / L; Renal function: Cr= 55 ml / min; Liver function: total bilirubin <= ULN × 1.5; ALT and AST <= ULN × 2.5; Coagulation function: international normalized ratio of prothrombin time <= ULN × 1.5, and partial thromboplastin time is within the normal range; Pre-meal blood glucose <= 7mmol/L; 7. Effective contraceptive measures are required during the study period of women of childbearing age; 8. Patients or their legal representatives voluntarily participate in and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Severe mental illness; 3. Intraoperative exploration revealed that the tumor was not suitable for proximal gastrectomy or could not achieve the required lymph node dissection; 4. The general classification of the tumor is diffuse infiltration (Borrmanns type IV); 5. Preoperative or intraoperative detection of distant organ metastasis or extensive intra-abdominal metastasis; 6. Combined with simultaneous or metachronous other organ tumors; 7. Filed to complete radical surgery, palliative resection of the tumor; 8. Previous history of gastrointestinal surgery; 9. Previous history of neoadjuvant chemoradiation; 10. A serious concomitant disease that may have a survival period of < 5 years; 11. Cases that the investigator considered unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year RFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nutritional status; | — |
Countries
China
Contacts
Public ContactHuanqiu Chen
Jiangsu Cancer Hospital
Outcome results
None listed