Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Experimental group and Control group:0.4mg Fluconazole injection Qd 5 days
Sponsors
Guangzhou 1st People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Male or Female patient aged above 40 years old; 2. Patients who meet the 2018 GOLD guidelines for COPD diagnosis, and who are in the acute exacerbation of moderate to severe COPD according to the GOLD guidelines; 3. Patients showed no improvement or worsen symptoms after 5 days standardized treatment (methylprednisolone 40mg / day, anti-infective, aerosolized bronchodilators and other comprehensive treatment) according to the GOLD guidelines; 4. Sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined pneumonia, tuberculosis, lung cancer, bronchiectasis, interstitial lung disease, atelectasis, lung abscess, empyema, cystic fibrosis, granulomatous disease, obliterative bronchiolitis or recent pulmonary embolism, and pleural disease; 2. Myocardial infarction, unstable angina pectoris, grade 4 cardiac insufficiency, and decompensated pulmonary heart disease occurred in the past 3 months; 3. Severe liver and kidney failure, transaminase is more than 3 times the upper limit of reference range or creatinine clearance is less than 50 ml/min; 4. Identify fluconazole-resistant Candida infections, or other confirmed fungal infections other than Candida; 5. Organ transplantation or hematopoietic stem cell transplanters; 6. Immunosuppressive therapy is being used during chemotherapy or screening within 3 months prior to randomization. 7. Patients with absolute neutrophil counts <500/mm3; 8. Known HIV positive; 9. Women who are pregnant or breastfeeding, or women who plan to conceive or breastfeed during the study period. 10. Intolerant to azole according to the patient's medication history; 11. Pathogens that are not covered by antibiotics during the 5-day routine treatment and need to be adjusted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of stay in hospital; | — |
Countries
China
Contacts
Public ContactZiwen Zhao
Department of internal medicine, Guangzhou
Outcome results
None listed