serious burn
Conditions
Interventions
Control group:the "down ladder" antibiotic strategy group (mainly prophylactic use of tertiary antibiotics: Tanneng, imipenastatin, cefseril, meropenem, vancomycin, teicoplanin, etc.)
Experimental:"ladder" antibiotic strategy group (mainly prophylactic use of secondary antibiotics: cefoperazone sulbactam, piperacillin sulbactam, cefoperazone Tabazol, ceftazidime, cefotaxime, cefope
Sponsors
Institute of Burn Research, Southwest Hospital, the Third Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient takes part in the test voluntarily and signs the informed consent statement; 2. TBSA >= 30%, or III degree TBSA >= 10%; 3. Admitted within 28 hours after injury; 4. Aged between 18 to 65 years, no gender limitation.
Exclusion criteria
Exclusion criteria: 1. Patient with tumor, AIDS, diabetes or autoimmune diseases; 2. Patient with specific infection such as tuberculosis, legionella and others; 3. Pregnant or breastfeeding woman; 4. Patient with systemic failure; 5. Patient with coagulation dysfunction; 6. Patient who suffered cardiac infraction or cerebrovascular accident within past 6 months; 7. Patient who has poor adaptivity and cannot complete treatment schedual of the trial; 8. Patient who has a serious disease of the heart, liver or kidney, or had a blood producing disorder, and inclination to bleed or bleeding disease;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection related index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs change index;Related indexes of microbial culture; | — |
Countries
China
Contacts
Public ContactGaoxing Luo
Institute of Burn Research, Southwest Hospital, the Third Military Medical University
Outcome results
None listed