tetralogy of fallot (pulmonary atresia)
Conditions
Interventions
01:N/A
02:Oral coenzyme Q10, 2.5mg, t.i.d.
03:Oral coenzyme Q10, 5mg, t.i.d.
04:Oral coenzyme Q10, 10mg, t.i.d.
05:Oral coenzyme Q10, 20mg, t.i.d.
Sponsors
Fuwai Central China Cardiovascualr Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 2 Years
Inclusion criteria
Inclusion criteria: Patients with tetralogy of fallot or pulmonary atresia undergoing radical surgery in the children's heart center of fuwai central China cardiovascular hospital Weight<15kg Multiple resting oxygen saturation measurements < 85%
Exclusion criteria
Exclusion criteria: 1. History of previous cardiac surgery; 2. Chromosomal abnormalities; 3. Respiratory diseases; 4. Immunodeficiency disease; 5. Gastrointestinal diseases that affect coenzyme Q10 absorption 6. Preoperative positive inotropic drugs or circulation aids support; 7. Take Coenzyme Q10 2 weeks before admission; 8. Other antioxidants (vitamin C, E, A) and myocardial protectors were taken 2 weeks before admission 9. Participated in other clinical trials in the last 3 months; 10. Take warfarin 2 weeks before admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac troponin T; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac troponin T;CK-MB;IL-6;inotropic score;left ventricular ejection fraction;left ventricular end-systolic diameter,;left ventricular end-diastolic diameter;fractional shortening;ICU stay time;Mechanical ventilation time, from aortic cross-clamp release to extubation;Postoperative hospitalization time;postoperative complications;in-hospital mortality;Plasma coenzyme Q10; | — |
Countries
China
Contacts
Public ContactFan Taibing
Pediatric Cardiac Surgery, Fuwai Central China Cardiovascualr Hospital
Outcome results
None listed