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Non-randomized concurrent controlled trial: The effects of short-term sleep deprivation on ANP expression in blood, intestinal flora and systemic immune function in ICU patients

Non-randomized concurrent controlled trial: The effects of short-term sleep deprivation on ANP expression in blood, intestinal flora and systemic immune function in ICU patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900025497
Enrollment
Unknown
Registered
2019-08-29
Start date
2019-08-20
Completion date
Unknown
Last updated
2019-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short-term sleep deprivation in the ICU

Interventions

Sleep deprivation group:none
Control group without sleep deprivation:none

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for ICU patients: 1. Aged >=18 years; 2. Patients can follow instructions; 3. Agree to participate in this study. Inclusion criteria for healthy volunteers: 1. Aged >=18 years; 2. Patients can follow instructions; 3. Agree to participate in this study.

Exclusion criteria

Exclusion criteria: Exclusion criteria for ICU patients: 1. With visual and hearing impairment; 2. Intestinal perforation causes uncontrolled infection of the abdominal cavity; 3. Delirium was present at admission to the ICU; 4. RASS score for sedation30 days; 6. Deafness, neurodegenerative diseases (Parkinson's disease, Alzheimer's disease, etc.); 7. Acute brain injury (traumatic brain injury, SAH, acute ischemic stroke, acute intracranial hemorrhage, acute intracranial infection); 8. Acute myocardial infarction; 9. Chronic kidney disease or dialysis; 10. Alcohol dependence, mental illness or severe cognitive impairment; 11. Pregnant and lactating women; 12. Long-term insomnia before admission to ICU; 13. Unwilling or unwilling to provide informed consent or poor compliance. Exclusion criteria for healthy volunteers: 1. With visual and hearing impairment; 2. Digestive system and other chronic diseases; 3. Insomnia; 4. Deafness, neurodegenerative diseases; 5. Alcohol dependence, mental illness or severe cognitive impairment; 6. Pregnant or lactating women; 7. Reluctance to provide informed consent or poor compliance.

Design outcomes

Primary

MeasureTime frame
Serum ANP expression;Intestinal flora diversity and relative abundance;Percentage change in absolute value of blood lymphocytes;—

Secondary

MeasureTime frame
Secondary infection;ICU days;28-day mortality;—

Countries

China

Contacts

Public ContactJiancheng Zhang

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

zhjcheng1@126.com+86 13554105815

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026