Effects of tDCS with different stimulation protocols on post-stroke cognitive impairment and the mechanism of resting-state network

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025467

Enrollment

Unknown

Registered

2019-08-27

Start date

2019-09-01

Completion date

Unknown

Last updated

2019-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

A:online-tDCS

B:offline-tDCS

CC:shamtDCS

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) stroke patients who meet the diagnostic criteria formulated by the fourth national academic conference on cerebrovascular diseases in 1995; (2) the course of the first stroke was 1 week to 6 months; (3) the dominant hand is the right hand; (4) aged 40-70 years; (5) mild to moderate cognitive impairment (10 = 93.8); (7) neurological symptoms with stable vital signs and no progress; (8) voluntarily participate and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) complete damage to the left frontal lobe; (2) there are the following contraindications for tDCS treatment: patients using implantable electronic devices (such as pacemakers); Patients with intracranial metal implants; Patients with fever, electrolyte disturbance or unstable vital signs; Pregnant women and children; Patients with bleeding tendencies; Patients with increased intracranial pressure; Patients with severe heart disease or other medical conditions; Patients with acute massive cerebral infarction; Epilepsy patients and those who take drugs that can cause epilepsy; Patients with implanted devices with metal parts in the treatment area;Patients with hyperalgesia in the stimulation area; Local skin injury or inflammation; (3) Cognitive decline before stroke; (4) Any neuropsychiatric illness and obvious affective disorder may affect the test results; (5) Any other factors affecting assessment and treatment.

Design outcomes

Primary

Measure	Time frame
Montreal cognitive assessment;	—

Secondary

Measure	Time frame
Stroop test;Trail Making Test;digit span test;Hamilton anxiety rating scale;Hamilton Depression Scale;mini-mental state examination;modified bathel index;BDNF genetic polymorphism;COMT genetic polymorphism;fMRI;event-related potential;	—

Countries

China

Contacts

Public ContactLi Lili

Rehabilitation Department, The Third Affiliated Hospital of Sun Yat-Sen University

lovelyxt2008@163.com+86 13751872809

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026