High-Risk Acute Myeloid Leukemia
Conditions
Interventions
Case series:CLAG-M Bridging to HSCT
Sponsors
Department of Hematology, the Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
14 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. male and female aged 14~55 years old; 2. diagnosis with refractory / recurrent acute myeloid leukemia: (1) Patients were treated with standard induced remission regimen for 2 courses but didn't achieve remission . (2) Those who recur within 6 months after the first remission, also known as early recurrence. (3) Recurrence occurred 6 months after the first remission, but the original induced remission regimen failed to achieve CR again. (4) Secondary or multiple recurrence. (5) Recurrence after transplantation. 4. ECOG score 0~2; 5. HLA-Matched donor is available; 6. normal cardiac function: ejection fraction >=50%; 7. blood bilirubin <=35 umol/L, AST/ALT below 2 times the upper limit of normal value; 8. serum creatinine <=130 umol/L; 9. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1 diagnosed as AML-M3 according to FAB classification(acute promyelocytic leukemia); 2. severe infection was not controlled before transplantation; 3. non-myeloaball allogenic hematopoietic stem cell transplantation was performed; 4. patients with cardiac insufficiency (ejection fraction 34umol/L, AST/ALT >2 times the upper limit of normal value; 6. renal insufficiency (serum creatinine >130umol/L) 7. refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CR rate;overall survival rate;Disease-free survival rate;relapse rate;Mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| engraftment rate;Chemotherapeutic toxicity;acute and chronic complications associated in Allo-HSCT; | — |
Countries
China
Contacts
Public ContactZhang Jingwen
Department of Hematology, the Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed