gastroesophageal reflux disease
Conditions
Interventions
Typical symptom patients:Gastric juice and esophageal mucosa were collected
healthy control:Gastric juice and esophageal mucosa were collected
Sponsors
Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, patients with typical symptoms of gastroesophageal reflux: heartburn, reflux and age-gender matched group. 2. Symptoms persisted for more than three months, and more than three times a week. 3. HRM,24h pH-impedance monitoring and gastroscopy were performed in our hospital. 4. Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Received antibiotics in the last 8 weeks;Those who have received acid suppression therapy or power boosting drugs in the last 2 weeks. 2. Previous history of gastroesophageal surgery. 3. Oral, digestive or systemic infection. 4. Endoscopic examination showed esophageal and gastric varices. 5. Poor blood pressure, hemoglobin, oagulation and other basic conditions. 6. Patients who are taking drugs that affect blood clotting. 7. Pregnant women. 8. Contraindication to endoscopy and esophageal acid and pressure testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in microbiota structure; | — |
Countries
China
Contacts
Public ContactYinglian Xiao
Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed