perioperative stress ulcer prophylaxis in orthopedic patients
Conditions
Interventions
Hip and knee replacement treatment group:Application of antigastric acid drugs
Hip and knee replacement control group:Routine management
Elderly trauma PPI group:PPI
Elderly trauma H2 receptor antagonist group:H2 receptor receptor antagonist
Sponsors
Beijing Hospitals Authority
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) the age of patients with hip and knee replacement should over 18 years old; Aged patients should over 65 years old; (2) patients planning to undergo surgery; (3) estimated length of hospitalization should over 48 hours.
Exclusion criteria
Exclusion criteria: (1) gestation and lactation; (2) preoperative acid-inhibiting treatment or indications of acid-inhibiting treatment, such as peptic ulcer, reflux esophagitis, drobe syndrome, gastrointestinal bleeding, and receiving dual anti-platelet therapy (aspirin and clopidogrel); (3) patients with digestive system symptoms such as nausea, vomiting, abdominal pain, abdominal distension and acid reflux before surgery. (4) severe liver dysfunction (child-pugh score grade C); (5) severe renal insufficiency (creatinine clearance rate < 30mL/min); (6) solid organ transplantation (liver transplantation, kidney transplantation, etc.); (7) the clinical evaluation is not suitable for inclusion in the group (at least two project team members should agree, including at least one clinical expert, to record the reasons for the ineligibility).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| ALT;ALP;serum creatinine; | — |
Countries
China
Contacts
Public ContactZhen jiancun
Beijing Jishuitan Hospital
Outcome results
None listed