Benign prostatic hyperplasia
Conditions
Interventions
Group 1:a1-blockers
Group 2:a1-blockers and M-blockers
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male BPH patients aged 45-80 years old; 2. IPSS score is greater than or equal to 8; 3. Willingness to receive medication; 4. Qmax is less than or equal to 15; 5. Voided volume during free flow is greater than or equal to 120ml; 6. Urinary B-ultrasound found that the prostate volume is greater than 20ml.
Exclusion criteria
Exclusion criteria: 1.Patients with serum PSA>10 ng/ml, suspected and diagnosed with prostate cancer; 2.Severe obstruction of bladder outlet (residual urine greater than 200ml or Qmax less than 5mL/s); 3.Baseline urodynamics showed severe damage to the bladder detrusor function; 4.The prostate volume is greater than 80ml; 5.Patients treated with 5a reductase inhibitors, alpha blockers, and M receptor antagonists within 3 months; 6.Liver and kidney dysfunction, allergic to research drugs, or patients with drug contraindications; 7.History of orthostatic hypotension or syncope, history of acute urinary retention, history of urinary tract infection or recurrent urinary tract infection (greater than or equal to 3 times/year); 8.History of previous prostate and bladder neck surgery; 9.Neurogenic (multiple sclerosis, spinal cord injury, Parkinson's disease) bladder dysfunction, diabetic neuropathy; 10.Bladder outlet obstruction caused by other causes besides BPH.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| B-ultrasonography of urinary system; | — |
Secondary
| Measure | Time frame |
|---|---|
| OABSS;IPSS;Urodynamic test;Voiding diary; | — |
Countries
China
Contacts
Public ContactKunjie WANG
Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University
Outcome results
None listed