Bacterial early-onset neonatal infection
Conditions
Interventions
Gold Standard:1.It has clinical manifestations of infection and accords with any of the following
2. Pathogenic bacteria results are positive in blood or aseptic body fluid culture
3. If opportunistic pathogens can be cultured in blood culture, homologous bacteria must be cultured in another part of blood, or in aseptic body
Index test:The 
expression 
of 
and 
TREM-1 
on 
monocytes 
neutrophils 
in 
blood 
were 
by 
Sponsors
Qingpu Branch, Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Newborns with high risk factors for infection such as premature rupture of membranes, gestational diabetes mellitus and muddy amniotic fluid, or completely normal; 2. Cases with gestational age of 37-42 weeks; 3. Neonates of boys or girls; 4. Neither mother nor newborn received antibiotic treatment; 5. Mothers did not use hormones or other drugs in the third trimester of pregnancy; 6. Neonates have no serious heart, lung, liver, kidney and other important organ dysfunction; 7. Neonatal organ-free tissue deformity and various hereditary diseases; 8. Written informed consent with exact date obtained.
Exclusion criteria
Exclusion criteria: 1. Neonates have any diseases other than infection such as organ malformations and various hereditary diseases, as well as heart, lung, liver, kidney and other important organ dysfunction; 2. Neonates with marked symptoms of viral or fungal infections, or mothers have history of fungal or viral infections; 3. Mothers have diseases that affect the level of biomarkers in the blood, such as organ inflammation, heart disease and cancer; 4. Mothers and newborns were treated with antibiotics before cord blood samples was collected; 5. Mothers used hormones, immunosuppressants and other drugs in the third trimester of pregnancy; 6. The discharged cases within 7 days after birth can not cooperate with 7 days follow-up due to psychological, social, family and geographical reasons; 7. Informed consent refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD64;TREM-1; | — |
Countries
China
Contacts
Public ContactXu Lingmin
Qingpu Branch, Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed