Cervical Cancer
Conditions
Interventions
Experimental group:NACT+CCRT
Sponsors
Ruijin Hospital Affiliated to Medical school of Shanghai Jiao Tong University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~70 year old; 2. Histologically confirmed squamous carcinomma, adenocarcinoma or adeno-squamous carcinoma of the cervix; 3. FIGO (2009)stage IIB-IVA as evaluated by two senior gynecological oncologists; 4. Performance status ECOG =40KG; 6. White blood cell count >=4.0x10^9/LHemoglobin >=70g/L; platelets >=100.0x10^9/L; Liver function: serum bilirubin <=1.0 N; ALT/AST <=1.0 N; ALP <=1.0 N; Renal function: BUN <=1.0 N, Cr<=1.0 N; 7. No active TB; 8. Negative pregnancy test, HCG (-); 9. Negative HIV test; 10. Capable of providing written or witnessed informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous pelvic malignant diseases with chemotherapy or radiotherapy; 2. Having received pelvic or abdominal radiotherapy; 3. Supra-renal lymph nodes metastasis or distant metastasis detected by PET-CT or chest/abdominal CT; 4. Acute infection or uncontrolled severe medical condition; 5. Pregnant or lactating; 6. Intestinal Perforation or acute ileus; 7. Uncontrolled cardiac disease (defined as a cardiac function which would preclude hydration during a cisplatin administration and any contraindication to paclitaxel); 8. Adrenocortical insufficiency; 9. Bone marrow metastasis; 10. Not meeting requirements for chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease free survival;Overall survival;2 year disease free survival;2 year overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate after NACT;Response rate after completion of treatment; | — |
Countries
China
Contacts
Public ContactFENG WEIWEI
Ruijin Hospital attached to Medical school of Shanghai Jiao Tong University
Outcome results
None listed