Primary microvascular angina
Conditions
Interventions
1:conventional medical treatment (Aspirin 100mg QN, Atorvastatin 20mg QN, Isosorbide mononitrate tablet 40mg QD, Metoprolol ZOK 47.5mg QD, Perindopril 4mg QD)
2:conventional medical treatment and diltiazem
3:conventional medical treatment and beraprost Sodium
4:conventional medical treatment and Nicodil
Sponsors
Hangzhou Red Cross Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged 18 to 75 years; (1) Typical labor-type angina for at least half a year. (2) Electrocardiogram conventional 12-lead trace, ST-segment offset measurement 80 ms after J point. (3) Exercise flat test positive(ST-segment ischemic down-shift >= 0.01mm) or dynamic ECG monitoring showed at least one ST-segment ischemic down-shift >=0.01 mm. (4) The left ventricular function of the echocardiogram was normal, and the left ventricular ejection fraction (LVEF) was >55%. (5) Coronary angiography showed normal or near normal (contrast findings suggest normal or irregular epicardial coronary vessel wall, mild stenosis of lumen discontinuity, stenosis <20%), no spontaneous coronary artery spasm Performance, TIMI blood flow 1-2 patients. (6) CMR confirmed the presence of coronary microcirculation.
Exclusion criteria
Exclusion criteria: (1) Organic heart disease including coronary artery spasm, coronary artery bridge, primary cardiomyopathy, congenital heart disease, valvular heart disease, hypertrophic cardiomyopathy, pulmonary heart disease, hypertensive heart disease; (2) Myocardial injury: including myocarditis, systemic and myocardial damage; (3) Clear history of myocardial infarction, coronary intervention, or coronary artery bypass grafting; (4) Arrhythmia requiring drug control; (5) Complete left bundle branch block, II and III degree atrioventricular block, sick sinus syndrome; (6) Severe congestive heart failure; (7) Malignant tumors; (8) Other diseases such as lung, esophagus, and aortic dissection that can cause chest pain; (9) Severe liver and kidney dysfunction; (10) Patients with acute or chronic inflammatory diseases and severe trauma; (11) Endocrine system diseases; (12) Anemia; (13) Peripheral vascular disease; (14) Active bile duct disease; (15) Ethanol intake; (16) Magnetic resonance examination for contraindicated patients; (17) Those who cannot adhere to the drugs; (18) Pregnancy and lactation women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovascular magnetic resonance;von Willebrand facto;homocysteine; | — |
Countries
China
Contacts
Public ContactQi Huang
Hangzhou Red Cross Hospital
Outcome results
None listed