perioperative neurocognitive disorders
Conditions
Interventions
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: Aged 60-85 years, ASA I-III, received elective surgery of unilateral lower extremity orthopedics, the anesthesia lasted more than 2 hours.
Exclusion criteria
Exclusion criteria: Patients with severe central nervous system and psychological diseases that cannot finish the test (such as sequelae of cerebral infarction , barylalia, inability to write, etc.), alcoholism or drug dependence, severe liver and kidney dysfunction (child-pugh grade C; uremic syndrome with replacement therapy), severe electrolyte disturbances, uncontrolled cardiovascular and respiratory system disease, severe coagulopathy, puncture site infection, lumbar vertebral fracture, serious visual impairment dysaudia and parachromatopsia or hypochromatopsia, sinus bradycardia and conduction block, patients with claustrophobia, patients with metal implants, or cardiac pacemaker ,patients who are participating in other clinical trials, other reasons which are not suitable for the clinical subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PND 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of PND 1 month after surgery;Incidence of PND 1 year after surgery;mean diffusivity;fractional anisotropy;Radial Diffusivity;Axial Diffusivity;Amplitude of Low Frequency Fluctuations;Regional Homogeneity;renal cortical blood flow;Thickness of cerebral cortex; | — |
Countries
China
Contacts
Public ContactLiuZhiheng
Department of Anaesthesiology, Shenzhen Second People's Hospital
Outcome results
None listed