Non-small cell carcinoma
Conditions
Interventions
Case series:CalliSpheres can be loaded with drug-loading microspheres
Sponsors
The First People's Hospital of Chenzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: If the patient meets all of the following criteria, the patient may be enrolled in the study: (1) Aged >= 18 years, gender is not limited; (2) Pathological and/or cytological examination confirmed by fiberoptic bronchoscopy or CT-guided biopsy as NSCLC, TNM stage III-IVa, genetic test (EGFR, ALK gene test) negative or rejected / no economic ability to use target To the drug, no indication of surgery or rejection of surgery; (3) Progress after first-line chemotherapy and no head and other distant metastasis; (4) The expected survival period is greater than 3 months; (5) The US Eastern Oncology Cooperative Group (ECOG) has a physical status (PS) score of <= 2 points; (6) The pregnancy test for women of childbearing age must be negative; or male and female patients should agree to use effective contraception during the treatment period and for the following year; (7) The patient signed an informed consent form that agreed to participate in the trial study, which was able to follow up and was well compliant.
Exclusion criteria
Exclusion criteria: (1) Can perform surgical tumor resection; (2) Poor coagulation function INR>1.5, or anticoagulant therapy or known bleeding disorder; (3) Unstable coronary heart disease or recent myocardial infarction (within one year); (4) Recent infections require antibiotic treatment; (5) DSA shows that the tumor blood supply artery contains the anterior spinal artery and/or esophageal artery and cannot be avoided; the bronchial artery is too slender and the intubation is unsuccessful; the arteriovenous fistula is expected to be unable to embolize the microsphere; (6) Complications or social environment that can cause the subject to fail to follow the research plan or even endanger the safety of the patient; (7) With other primary tumors. The investigator judged that the subject had other factors that might cause the study to be terminated midway. For example, other serious diseases (including mental illness) require combined treatment, serious laboratory abnormalities, and family or society factor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;1 year, 2 year survival rate;Improvement in lung function;Improvement in living conditions;Safety evaluation; | — |
Countries
China
Contacts
Public ContactHaixue Dai
The First People's Hospital of Chenzhou
Outcome results
None listed