Remote Ischemic Conditioning Moyamoya Disease

Effects of Remote Ischemic Pre-and Post-Conditioning on Neurologic Complications in Adult Ischemic Moyamoya Disease Patients Undergoing Encephaloduroarteriosynangiosis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025278

Enrollment

Unknown

Registered

2019-08-20

Start date

2019-10-01

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moyamoya disease

Interventions

RIPC group:Remote limb ischemic preconditioning (RIPC) is consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, it is induced by a sphygmomanometer placed on bilateral arm and inflated

shame RIPC group:Sham RIPC group is consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, induced by a sphygmomanometer placed on bilateral arm and inflated to 60 mmHg for 5-min follow

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients who diagnosed with moyamoya disease; 2. Aged 18 to 65 years; 3. The onset symptoms manifested as ischemic symptoms (TIA or stroke) or atypical symptoms (headache, epilepsy or asymptomatic); 4. Able to receive the necessary imaging examination; 5. Patients who pre-agreed to the study.

Exclusion criteria

Exclusion criteria: 1. Prior cerebral hemorrhage history; 2. Other brain or cerebrovascular disease; 3. Previous history of revascularization surgery; 4. Dependent (mRS > 2); 5. Receive other type of revascularization surgery; 6. Peripheral blood vessel disease (especially subclavian arterial and upper limb artery stenosis or occlusion).

Design outcomes

Primary

Measure	Time frame
All cerebrovascular events (ischemic stroke, cerebral hemorrhage, transient neurological deficits) within 30 days post-surgery;All death or dependent (mRS > 2) within 30 days post-surgery;	—

Secondary

Measure	Time frame
The severity of the ischemic stroke after surgery;Number of patients occurred re-stroke at Follow-up Period;Number of patients dependent or death at follow-up period;Number of patients with improved neurological function at follow-up period;Perfusion status of patients at follow-up period;Number of patients with any side effects of remote ischemic preconditioning (RIPC) treatment;The presence of =1 new brain lesions on DWI within 48 hours after EDAS;	—

Measure

Time frame

The severity of the ischemic stroke after surgery;Number of patients occurred re-stroke at Follow-up Period;Number of patients dependent or death at follow-up period;Number of patients with improved neurological function at follow-up period;Perfusion status of patients at follow-up period;Number of patients with any side effects of remote ischemic preconditioning (RIPC) treatment;The presence of =1 new brain lesions on DWI within 48 hours after EDAS;

—

Countries

China

Contacts

Public ContactXun Ye

Beijing Tiantan Hospital, Capital Medical University

yexun79@hotmail.com+86 13426268801

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026