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Effects of precise anesthesia combined with indexes of consciousness (IoC1 and IoC2) on postoperative neuropsychiatric complications and outcomes in elderly patients

Effects of precise anesthesia combined with indexes of consciousness (IoC1 and IoC2) on postoperative neuropsychiatric complications and outcomes in elderly patients

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900025241
Enrollment
Unknown
Registered
2019-08-17
Start date
2019-08-19
Completion date
Unknown
Last updated
2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic urological surgery in patients

Interventions

Group 1:Adjusting the pumping speed of propofol to maintain IOC1 value between 40 and 60.
Group 2:BIS monitoring guides intravenous general anesthesia: The pump speed of propofol 3-5 mg/kg and remifentanil 0.2-0.5 ug/kg/min was adjusted to maintain BIS value between 50 and 60.

Sponsors

Department of Anaesthesia and Surgery, Xuanwu Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: ASA <= III, aged 65 ~ 85 years, patients undergoing laparoscopic urological surgery under intravenous general anesthesia.

Exclusion criteria

Exclusion criteria: Refusing to sign the informed consent; Cerebrovascular diseases within 6 months include cerebral hemorrhage or cerebral embolism history or neurological sequelae more than 6 months. Depression score > 16, simple mental state test (MMSE) < 23, years of education < 3; Severe impairment of vision, hearing and verbal communication; Preoperative seizures in 4 ~ 6 weeks unstable angina or acute myocardial infarction, cardiac function NYHA III ~ IV level; Patients with severe liver and kidney function; Patients with comorbidities of the intestine, such as ulcerative colitis and clonagna.

Design outcomes

Primary

MeasureTime frame
postoperative neuropsychiatric complications;

Countries

China

Contacts

Public ContactWang Tianlong

Department of Anaesthesia and Surgery, Xuanwu Hospital, Capital Medical University

wangtianlong@xwhosp.org+86 13910525304

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026