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Clinical Evaluation of Uygur Medicine Han Chuan Zupa granule in the Treatment of Chronic Airway Diseases

Uygur drug Hanchuan Zupa granules inhibit the pathogenesis of asthma by regulating the activation of NLRP3 Inflammasome through TLR4-JNK/P38-NF-?B Pathway

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900025228
Enrollment
Unknown
Registered
2019-08-17
Start date
2019-09-01
Completion date
Unknown
Last updated
2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma,Chronic obstructive pulmonary disease

Interventions

Experimental group:Standard treatment combined with Hanchuan Zupa granule treatment
Control group:Standard treatment

Sponsors

the First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with asthma: 1. Meet the diagnostic criteria defined in the GINA2017 guidelines; patients with mild to moderate asthma during the acute attack; currently, asthma is not well controlled (ACT score =30% and predicted 120% of predicted value) and those with obvious dyspnea during activity (Mahler BDI < 8); 3. Volunteer to join the study and sign a written consent form.

Exclusion criteria

Exclusion criteria: Patients with asthma: 1. Patients with poor compliance and speech conversation disorder, patients with a systemic use of glucocorticoids in the past four weeks, patients with structural pulmonary diseases such as chronic obstructive pulmonary disease, bronchiectasis and lung cancer, etc. 2. With severe cardiovascular and cerebrovascular, liver, kidney and hematopoietic system diseases; 3. those with a history of related drug allergy; pregnant women, lactating women or those who cannot exclude pregnancy. Patient with COPD: 1. In addition to COPD, there were other major diseases, such as asthma or bronchitis and other structural lung diseases and lung cancer and other lung substantive diseases; 2. Patients with severe cardiovascular, cerebrovascular, liver, kidney, hematopoietic system diseases; 3. have a history of related drug allergy.

Design outcomes

Primary

MeasureTime frame
Pulmonary function;Clinical symptom score;IgE;Blood routine;CAT score;Chest CT;Blood gas analysis;blood oxygen saturation;

Secondary

MeasureTime frame
Procalcitonin;Inflammatory factor;CRP;

Countries

China

Contacts

Public ContactXiaoyun Fan

the First Affiliated Hospital of Anhui Medical University

smallcloud2@126.com+86 13956988552

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026