primary angle-open glaucoma
Conditions
Interventions
morning dosing group: morning dosing group receive latanoprost/timolol at 08:00 and placebo at 20:00
evening dosing group:evening dosing group receive placebo at 08:00 and latanoprost/timolol at 20:00
Sponsors
Beijing Tongren Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years with primary open-angle glaucoma by gonioscopy for the first time; 2. IOP>21 mmHg; 3. characteristic glaucomatous optic disc damage; 4. characteristic glaucomatous Visual Field defects; 5. binocular vision better than 20/40.
Exclusion criteria
Exclusion criteria: Subjects have any condition preventing reliable applanation tonometry, inadequate visualization of the fundus, conjunctivitis, keratitis, uveitis, progressive retinal or optic nerve disease other than glaucoma, intraocular surgery or laser surgery, or severe ocular trauma at any time. Patients who had a risk of visual field or visual acuity worsening, had a cup-disc ratio of 0.8 or worse, were unwilling to accept a risk of iris color or eyelash changes, were at risk for uveitis or cystoid macular edema, had a history of ocular herpes simplex, or had a history of hypersensitivity to any components of the preparations used in this study were excluded from the study. A severe medical or psychiatric condition, inability to adhere to a treatment, reactive airway disease, second or third degree atrioventricular block, congestive heart failure, concomitant use of systemic beta-blockers, history of bronchial asthma, or pregnancy or nursing were also considered reasons for exclusion from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour intraocular pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate; | — |
Countries
China
Contacts
Public ContactShuning Li
Beijing Tongren Hospital of Capital Medical University
Outcome results
None listed