pulmonary artery hypertension
Conditions
Interventions
Case series:drug transition
Sponsors
Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. diagnosed of Pulmonary artery hypertension by right heart catheter:mean pulmonary pressure >=25mmHg,pulmonary capillary wedge pressure or end diastolic pressure of left ventrical3 wood; 3. take Bosentan for more than 6 months and had no drug transition in the past 6 months; 4. have no dysfuction of liver and renal function, or below the 3 times of the normal upper line; 5. Consider of transition from Bosentan to Ambrisentan because of financial burden.
Exclusion criteria
Exclusion criteria: 1. Risk stratification of the patients were high; 2. patients who have impairment of renal,liver and thyroid function(more than three times of normal upper limit) or have severe infection; 3. Change of treatment plan within 6 month, or have bosentan for less than 6 months; 4. Have no intention to participate or a low compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6 minite walking distance;echocardiography;NT-proBNP;SATMED-Q Scale; | — |
Countries
China
Contacts
Public ContactJiang Li
Second Xiangya Hospital of Central South University
Outcome results
None listed