Anti-NMDAR Encephalitis
Conditions
Interventions
group of good curative effect of hormone + group of bad curative effect of hormone (group of good curative effect of IVIg + group of bad curative effect of IVIg):Glucocorticoids + IVIg
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or above; 2. All patients met the diagnostic criteria agreed by Chinese experts in the diagnosis and treatment of autoimmune encephalitis: (1) Within 3 months, one or more of the six following major groups of symptoms occurred: abnormal (psychiatric) behavior or cognitive dysfunction, speech dysfunction, seizures, movement disorder, decreased level of consciousness, autonomic dysfunction, or central hypoventilation; (2) Positive results of anti-NMDAR antibodies in CSF; (3) Reasonable exclusion of other causes. 3. Patients who have signed an informed consent.
Exclusion criteria
Exclusion criteria: 1. HIV infection, meningitis, brain abscess, prion diseases, cerebral malaria, brain tumor, or a diagnosis of a noninfectious central nervous system disease, such as acute demyelinating encephalomyelitis (ADEM); 2. Patients with laboratory evidence of infectious encephalitis, for example, viral, bacteria, mycobacterium tuberculosis (TB), parasitic, or fungal; 3. Patients diagnosed with epilepsy, cerebral trauma, and/or other nervous system disease prior to the onset of encephalitis; 4. Patients with coexisting other positive autoimmune or neurologic paraneoplastic antibodies; 5. Pregnant women, lactating women, and women of childbearing age who are not willing to receive contraception during the first 4 weeks of admission and throughout the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-NMDAR titer;Metabonomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Seizure duration;Duration of mental symptoms;GOS;mRS??;28-day survival rate;Length of stay in ICU;Length of mechanical ventilation;All-cause mortality rate; | — |
Countries
China
Contacts
Public ContactFu Min
Intensive Care Unit, West China Hospital, Sichuan University
Outcome results
None listed