Osteogenic degeneration of the cervical intervertebral disc
Conditions
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The patient was diagnosed as cervical spondylosis based on clinical and radiological evidence. 2. Surgery for the first time was performed after at least 6 weeks conservative treatment, which was ineffective; 3. The surgical methods were either artificial cervical disc replacement (ACDR) or anterior cervical discectomy and fusion (ACDF).
Exclusion criteria
Exclusion criteria: 1. The cervical degeneration was serious, and the loss of intervertebral height was more than 80% of the adjacent normal segments. 2. Sufficient disc samples could not be obtained during operation. 3. Operative contraindications were found, such as poor cardiopulmonary function and intolerance to the surgery. 4. The patient had a history of neck injury or related surgery. 5. There was active hemorrhage or infection history of the patient. 6. There was a history of fracture, tumor, tuberculosis and other tissue-invasive diseases in the cervical spine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TGF-ß1;p-Smad2;p-Smad3; | — |
Countries
China
Contacts
Public ContactXing Yu
Dongzhimen Hospital, Beijing University of Chinese Medicine
Outcome results
None listed