Sudden Hearing Loss
Conditions
Interventions
High-dose Group:ginkgo biloba extract tablets, 80mg tid p.o.
Low-dose Group:ginkgo biloba extract tablets, 40mg tid p.o.
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 65 years; 2) With new-onset unilateral idiopathic sudden sensorineural hearing loss (SSNHL), and having a reduction in hearing >= 30dB in at least three consecutive frequencies compared with the contralateral ear in pure tone audiometry; 3) Whose contralateral ear functions normally, or has age-related hearing reduction*; 4) Having SSNHL for = grade 2, i.e. >= 18 points; 6) Without a history of tinnitus in both ears; 7) Without a history of ear conditions which may affect hearing; 8) Who signed the informed consent; 9) With follow-up compliance; * The criteria of age-related hearing reduction are: 18 <= age <65: PTA <= 25dB; 55 <=age < 60: PTA <= 35dB; 60 <= age < 65: PTA <= 40dB.
Exclusion criteria
Exclusion criteria: 1) With SSNHL with known cause; 2) Who were taking oral microcirculation-improving drugs or took them within three months before the trail, including but not limited to ginkgo leaf tablets, ginkgo biloba extract drops, Xuesaitong, Xueshuantong, lumbrokinase and prostaglandin tablets; 3) With severe comorbidities such as severe heart disease, cerebral infarction, poorly controlled hypertension, coagulation abnormalities, malignancies, heart failure, arrhythmia, conditions requiring hemodialysis, HBV, HCV and dementia; 4) Who are pregnant or plan to become pregnant in 12 months; 5) With a history of diagnosed depression, anxiety or mental disorders; 6) With a history of diagnosed immune-related diseases; 7) Without a complete medical record.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tinnitus handicap inventory;Visual Analogue Scale of Tinnitus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Threshold of Pure Tone Audiometry; | — |
Countries
China
Contacts
Public ContactYu Lisheng
Department of Otolaryngology, Peking University People's Hospital
Outcome results
None listed