Depressive disorder
Conditions
Interventions
probiotics:clostridium tyrosinate
fluoxetine:fluoxetine
combination therapy:clostridium tyrosinate+fluoxetine
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Subjects must meet the diagnostic criteria of depressive disorder for DSM-IV and been confirmed by the international neuropsychiatric brief interview questionnaire (MINI); (2) Untreated first episode; (3) Subjects were aged between 18 and 55 years; (4) The total score of HAMD scale (24 items) cann't lesser than 20 points; (5) Subjects voluntarily participate this study and sign the written informed consent.
Exclusion criteria
Exclusion criteria: (1) Subjects are suffering from other mental illness; (2) Subjects are suffering from other physical diseases, especially gastrointestinal diseases (requiring medication); (3) Subjects have serious suicidal tendencies and history of alcohol or other substance dependence abuse; (4) Subjects have family history of bipolar disorder, schizophrenia and other mental diseases; (5) Subjects received antibiotics and probiotics within the last 1 month; (6) Subjects are pregnant or lactating; (7) Subjects have participated in one clinical trial in the past 90 days or two or more clinical trials in the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| immune index;metabolic index;Intestinal flora abundance and diversity;intestinal mucosal barrier;Clinical symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI of brain; | — |
Countries
China
Contacts
Public ContactPenghong Liu
The First Hospital of Shanxi Medical University
Outcome results
None listed