migraine without aura
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Right hand; aged between 18-55 years, gender is not limited; 2. Education time >= 6 years; 3. Meet the above-mentioned IHS diagnostic criteria for aura without migraine; 4. There is a history of migraine for more than 1 year. The migraine first started before the age of 50. In the past 1 month and the baseline period, the average headache occurred 2-6 times per month; 5. BAI standard scores is less than 36 points, and BDI standard scores is less than 21 points; 6. The patient signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of head trauma, secondary headache, tension headache, intermittent headache, cluster headache and cardiovascular disease, digestive system diseases; 2. Those who have experienced major bowel resection or major gastrointestinal surgery in the past; 3. Mental patients, susceptible to infection and bleeding, allergies; 4. Pregnant women and lactating women; 5. Can not understand or record the headache diary; 6. Suffering from moderate constipation and diarrhea in the past 3 months; 7. In the past 1 month, he received medical treatment for cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, cystitis; 8. Antibiotics have been used in the past 3 months for 3 days or more; or have long-term use of drugs such as analgesics; 9. Received acupuncture or other preventive treatment in the past 3 months; 10. There are metal implants in the body, and other MRI examination contrabands such as claustrophobia; 11. In the MRI scan, severe head anatomical structures were found to be asymmetric or have clear lesions; 12. Patient has participated in similar researchers within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora data collection and processing;fMRI;headche diary;HIT-6;SF-MPQ;GSRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| BAI;BDI;SF-36;MMSE; | — |
Countries
China
Contacts
Chengdu University of Traditional Chinese Medicine