Diabetic atherosclerosis
Conditions
Interventions
Mild stenosis group:N/A
Moderate stenosis group:N/A
Severe stenosis/occlusion group:N/A
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The patient is between 40 and 70 years old; 2. All patients were diagnosed with type 2 diabetes according to the WHO (1999) diagnostic criteria for diabetes; 3. All patients are accompanied by diabetic foot and have indications for amputation, including: contraindications or intolerance of revascularization therapy and revascularization therapy, painful and difficult to relieve after resting or drug intervention, limbs People with extensive lesions and difficult to heal, severely infected with life-threatening.
Exclusion criteria
Exclusion criteria: 1. Gastric ulcer, gastrectomy; 2. Taking hormones or taking a history of metformin; 3. Immunosuppressive therapy; 4. Severe liver and kidney dysfunction; 5. Severe trauma; 6. History of malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ne-carboxymethyllysine (CML);Receptor for advanced glycation endproducts (RAGE);Galectin-3;Plaque area;Scavenger receptor;Plaque distribution; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum total cholesterol;Low-density lipoprotein;Glycated hemoglobin;Peroxisome proliferator-activated receptor (PPAR);Sortilin; | — |
Countries
China
Contacts
Public ContactZhongqun Wang
Department of Cardiology, Affiliated Hospital of Jiangsu University
Outcome results
None listed