vascular calcification
Conditions
Interventions
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The patient is between 40 and 70 years old; 2. All patients were diagnosed with type 2 diabetes according to the WHO (1999) diagnostic criteria for diabetes; 3. All patients are accompanied by diabetic foot and have indications for amputation, including: contraindications or intolerance of revascularization therapy and revascularization therapy, painful and difficult to relieve after resting or drug intervention, limbs People with extensive lesions and difficult to heal, severely infected with life-threatening.
Exclusion criteria
Exclusion criteria: 1. Gastric ulcer, gastrectomy; 2. Taking hormones or taking a history of metformin; 3. Immunosuppressive therapy; 4. Severe liver and kidney dysfunction; 5. Severe trauma; 6. History of malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ne-carboxymethyllysine (CML);Receptor for advanced glycation endproducts (RAGE);Galectin-3;Sortilin;Calcium nodule morphology;Calcium content;Matrix vesicle; | — |
Secondary
| Measure | Time frame |
|---|---|
| N-acetylglucosamine-1-phosphate transferase subunits alpha and beta (GNPTAB);Nuclear Factor of Activated T Cells 1 (NFATC1);Serum total cholesterol;Low-density lipoprotein;Glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactZhongqun Wang
Department of Cardiology, Affiliated Hospital of Jiangsu University
Outcome results
None listed