Australasian Severe Asthma Network (ASAN) in China: a Real-World, Multicenter, Prospective Cohort Study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900025115

Enrollment

Unknown

Registered

2019-08-12

Start date

2019-09-01

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

Severe asthma, SA:N/A

Non-severe asthma, NSA:N/A

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Asthma patients: 1. Aged >=18 years, gender not limited; 2. The criteria for the diagnosis of asthma are in line with GINA and China's guidelines for the diagnosis and treatment of asthma. 3. Stable disease with no respiratory infection, asthma exacerbation, or change in maintenance therapy in the 4 weeks preceding screening. 4. Voluntary participation and signed the informed consent. Patients with severe asthma (SA): 1. Confirmed in the screening visit or in the past ten years in the medical record has any of the following variable airflow obstruction (VAO) evidence: including: (1) Bronchial provocation tests (BCT) positive; (2) Bronchial dilation Test BDT) positive: FEV1 increased 12% and its absolute value increased 200mL compared with that before the use of bronchodiastolic agent. (3) > 12% of PEF variation was monitored for at least 1 week. (4) > 12% mutation rate of FEV1 (measured twice within 2 months); 2. Although following GINA 4-5 level recommended treatment (such as high dose ICS, budesonide > 800 µg, fluticasone > 500µg ), patients still cannot achieve the control of asthma; 3. Only when following GINA 4-5 levels of recommended treatment such as high dose ICS, budesonide > 800 µg, fluticasone > 500 ug), can asthma control be maintained; Patients with non-severe asthma (NSA) : 1. Using maintainance dose of inhaled treatments; 2. Asthma was controlled, ACQ 20.

Exclusion criteria

Exclusion criteria: 1. Have received heart, lung or thoracic surgery; 2. Pregnant or lactating women; 3. Can not cooperate with sputum induction or lung function operator.

Design outcomes

Primary

Measure	Time frame
Skin Prick Test, SPT;Fractional exhaled Nitric Oxide,FeNO;pulmonary function testing;	—

Countries

China

Contacts

Public ContactWang Gang

West China Hospital, Sichuan University

wong-gang@126.com+86 18980602099

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026