critically ill patients
Conditions
Interventions
Nabuffine group:Nabuffine
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Surgical patients; 2. CPOT score >=3 points; 3. Aged 18 to 75 years; 4. The ICU stay time is expected to be >=48h; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who need cardiopulmonary resuscitation, or have abnormal ventilation function (abnormal ventilator function, decreased respiratory driving force, increased airway resistance or airway obstruction), or abnormal oxygenation. 2. Apache II score >=23. 3. Suffering from esophageal reflux disease, severe gastrointestinal injury AGI score >=3 points. 4. Long-term use of benzodiazepine sedatives and opioid analgesics. 5. Delirium and alcohol withdrawal symptoms exist. 6. Severe liver dysfunction (Child-Pugh Grade C). 7. Bronchial asthma or COPD, myasthenia gravis patients. 8. Severe brain injury, brain tumor, intracranial hypertension and other patients prone to respiratory depression. 9. Patients who have been selected for other clinical trials. 10. Study drug allergy or other taboos. 11. Pregnant or lactating women. 12. Patients themselves or their legal authorized representatives are not willing to provide informed consent. 13. There are factors that increase the risks associated with participating in the study (such as severe hypotension) or potential disputes. According to the judgment of the researchers, they are not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First defecation or exhaust time; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of first eating;the number of nausea and vomiting within 48 hours;AGI score;the use of gastrointestinal motility drugs;Dosage and adjustment times of analgesic and sedative drugs;Spending during ICU;length of hospital stay;short-term mortality rate;Biochemical indexes;SOFA Score;APACHE II Score;Basic vital signs; | — |
Countries
China
Contacts
Public ContactZhang Xijing
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed