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UPLC-MS/MS method for determination of the concentration of mycophenolic acid metabolizing from mycophenolate mofetil in plasma of children with nephrotic syndrome

UPLC-MS/MS method for determination of the concentration of mycophenolic acid metabolizing from mycophenolate mofetil in plasma of children with nephrotic syndrome

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900025066
Enrollment
Unknown
Registered
2019-08-09
Start date
2019-08-01
Completion date
Unknown
Last updated
2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrotic syndrome

Interventions

nephrotic syndrome in children Group:Nil
Healthy adult Group:Nil

Sponsors

Children's Hospital Affiliated to Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Inclusion criteria for children with nephrotic syndrome (1) Aged 8-18 years old; (2) Comply with the diagnostic criteria for nephrotic syndrome (see Appendix 1 and Appendix 2 for details); (3) Agree to sign the informed consent form; (4) Do not take mycophenolate or tacrolimus within 3 months; 2. Healthy adult inclusion criteria: (1) Agree to sign the informed consent form; (2) Aged 18 to 60 years old; (3) Those who have not taken any drugs within 1 month.

Exclusion criteria

Exclusion criteria: (1) Those who have chronic infection or active infection (2) Those who have a cold or a fever; (3) Those who have anemia; (4) Those who stayed up late the night before; the girls before and after menstruation; (5) Adults who are pregnant; (6) Those Those who have infectious diseases; (7) Heart, vascular system and other diseases are not suitable for blood donors; (8) Those who have mental illness or depression.

Design outcomes

Primary

MeasureTime frame
Blood concentration;

Countries

China

Contacts

Public ContactJingjing Wang

Children's Hospital Affiliated to Zhejiang University School of Medicine

57347484@qq.com+86 13588785926

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026