Alzheimer's disease
Conditions
Interventions
Group 3:Transcranial magnetic stimulation
Group 4:Sham Transcranial magnetic stimulation
Group 5:Multi-target transcranial magnetic stimulation
Group 6:Electromagnetic combined stimulation
Group 7:Multi-target transcranial magnetic stimulation with intelligent rehabilitation
Group 8:Electromagnetic combined stimulation with intelligent rehabilitation
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 50-75 years; 2. It meets the diagnostic criteria for AD set by the National institute on aging -AD institute (NIA-AA) in 2011; 3. MMSE<=23?; 4. CDR:1-2; 5. HAMD<17; 6. Hachinski<4; 7. According to the Edinburgh bias test, all are right-handed; 8. Long-term follow-up was agreed and accompanied by qualified informed persons at each follow-up.
Exclusion criteria
Exclusion criteria: 1. Complicated with other neurological diseases and serious diseases of heart, liver, lung and kidney; 2. There are metallic foreign body in the body, such as pacemaker, DBS treatment device, bracket; 3. Those who take benzodiazepines or have a history of drug abuse; 4. Patients with MDD and other severe mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| FMRI;TMS-EEG; | — |
Countries
China
Contacts
Public ContactWang yuping
Xuanwu Hospital Capital Medical University
Outcome results
None listed