Effect of Dexmedetomidine on Inflammatory Factors and TGF-ß/smad Signal Pathway During One-Lung Ventilation-Related Lung Injury During Thoracoscopy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025040

Enrollment

Unknown

Registered

2019-08-08

Start date

2019-08-12

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

One-lung ventilation-related lung injury

Interventions

1:Intravenous infusion of dexmedetomidine

2:Intravenous infusion of normal saline

Eligibility

Sex/Gender

All

Age

35 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. This study was approved by the ethics committee of our hospital and signed an informed consent with the patient or his family members. 2. All patients were classified according to ASA grade I-II, aged 35-64 years, with body mass index < 30kg/m2.

Exclusion criteria

Exclusion criteria: Patients with serious cardiovascular and cerebrovascular diseases, endocrine or immune system diseases.

Design outcomes

Primary

Measure	Time frame
IL-6;TNF-a;TGF-ß;Smad;	—

Countries

China

Contacts

Public ContactWang Lei

West Hospital Anesthesiology Department, Baoding First Central Hospital

156350565@qq.com+86 18617786107

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026