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Construction of a population pharmacokinetic model of polymyxin B in adult Chinese and optimization of its dosage regimen

Construction of a population pharmacokinetic model of polymyxin B in adult Chinese and optimization of its dosage regimen

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900025031
Enrollment
Unknown
Registered
2019-08-08
Start date
2019-09-01
Completion date
Unknown
Last updated
2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gram-negative bacilli infection

Interventions

Case Series:NA

Sponsors

The First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Greater than 18 years old, male or female; 2. Patient with Gram-negative bacilli infection ; 3. Patients treated with polymyxin B for more than 48 hours 4. At least one steady-state plasma concentration can be obtained;

Exclusion criteria

Exclusion criteria: 1.Patients who died within 24 hours after the use of polymyxin B.

Design outcomes

Primary

MeasureTime frame
Plasma concentration;leukocyte;Neutrophil;C-Reactive Protein;Procalcitonin;Clinical symptoms;—

Secondary

MeasureTime frame
Age;Gender;Weight;—

Countries

China

Contacts

Public ContactZhang Chunhong

The First Affiliated Hospital of Wenzhou Medical University

zch760217@163.com+86 13968879402

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026