Research for Minimally Invasive Closed-Loop Neuromodulation for Local Circuits of Cognitive Impairment

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025019

Enrollment

Unknown

Registered

2019-08-07

Start date

2019-08-15

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease

Interventions

Minimally Invasive Closed-Loop Neuromodulation for 12 Weeks:Minimally Invasive Closed-Loop Neuromodulation

Minimally Invasive Closed-Loop Neuromodulation for 24 Weeks:Minimally Invasive Closed-Loop Neuromodulation

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 50 to 75 years; 2. It meets the diagnostic criteria for AD set by the National institute on aging -AD institute (NIA-AA) in 2011; 3. MMSE <= 23?; 4. CDR:1-2; 5. HAMD< 17; 6. Hachinski<4; 7. According to the Edinburgh bias test, all are right-handed; 8. Long-term follow-up was agreed and accompanied by qualified informed persons at each follow-up.

Exclusion criteria

Exclusion criteria: 1. Complicated with other neurological diseases and serious diseases of heart, liver, lung and kidney; 2. There are metallic foreign body in the body, such as pacemaker, DBS treatment device, bracket; 3. Those who take benzodiazepines or have a history of drug abuse; 4. Patients with MDD and other severe mental illness; 5. Those who had a history of intracranial surgery; 6. Refusing surgery.

Design outcomes

Primary

Measure	Time frame
Neuropsychological Scale;	—

Secondary

Measure	Time frame
FMRI;TMS-EEG;	—

Countries

China

Contacts

Public ContactWang Yuping

Xuanwu Hospital Capital Medical University

wangyuping01@sina.cn+86 10-83198273

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026