Total knee arthroplasty
Conditions
Interventions
group 1:Intravenous infusion of 1g of tranexamic acid at 3 hours after surgery
group 2:Intravenous infusion of 1g of tranexamic acid at 3, 6, and 12 hours after surgery
Sponsors
Guanghua Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as rheumatoid arthritis according to the "Classification of Rheumatoid Arthritis" revised by the American College of Rheumatology in 1978 and the classification of rheumatoid arthritis by the American College of Rheumatology and the European Union of Rheumatology in 2010. Kellgren-LawrenceX line is graded III or IV; 2. Aged 50-75 years; 3. Initial unilateral TKA surgery; 4. Perioperative TXA antifibrinolytic therapy; 5. Preoperative hemoglobin, The coagulation function is normal.
Exclusion criteria
Exclusion criteria: 1. Other types of arthritis (such as primary arthritis, post-traumatic osteoarthritis, gouty osteoarthritis, haemophilic osteoarthritis, and tuberculous arthritis); 2. Bilateral knee arthroplasty (RA patients); 3. Severe cardiovascular disease (such as myocardial infarction, atrial fibrillation, angina pectoris, and cardiac failure) or cerebrovascular disease (such as cerebral infarction and cerebral haemorrhage); and 4. Prolonged use of oral anticoagulant drugs (such as aspirin, warfarin, and clopidogrel).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin;The blood loss;transfusion rate; | — |
Countries
China
Contacts
Public ContactXiao Lianbo
Guanghua Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed