Effect of ulinastatin combined with dexmetiomide on cognitive impairment and inflammatory response in elderly patients after general anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024994

Enrollment

Unknown

Registered

2019-08-06

Start date

2019-09-01

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive impairment

Interventions

blank control group:Sodium chloride injection

Dexmedetomidine group:Dexmedetomidine

Dexmedetomidine ulinastatin group:Dexmedetomidine+Ulinastatin

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: ASA I~III grade; aged 65 to 85 years; scheduled laparoscopic colorectal cancer surgery under general anesthesia; all patients and their families were informed and willing to cooperate with the experiment.

Exclusion criteria

Exclusion criteria: 1) there were long-term drinking history, neurological, muscle and endocrine system disease history, mental system disease history: 2) long-term history of antimelancholy and antianxiety and other neuropsychotic drugs; 3) cardiovascular and respiratory major disease history and severe damage of liver and kidney function; 4) patients who could not successfully complete mental function test before operation; 5) patients with body mass index (BMI) less than 18.5 or more than 25.

Design outcomes

Primary

Measure	Time frame
inflammatory cytokines (IL-1ß, IL-6, S100 ß, TNF-a);Neuropsychological test;Postoperative wound pain;Incidence of POCD;	—

Countries

China

Contacts

Public ContactZhang Chen

Hai'an Hospital affiliated to Nantong University

296227324@qq.com+86 13776993121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026