premature ventricular beats
Conditions
Interventions
Experimental medicine group:Xinsuning capsule, placebo of metoprolol tartrate
Positive medicine group:Metoprolol tartrate, placebo of Xinsuning capsule
the group of combining traditiaonal Chinese Medicine and western medicine:Xinsuning capsule, Metoprolol tartrate
placebo group:placebo of Xinsuning capsule, placebo of Metoprolol tartrate
Sponsors
Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Signing the informed consent voluntarily; 2. Aged 18 to 75 years; 3. In line with the western medicine diagnosis of premature ventricular contraction and meeting the following indicators: ventricular premature beat >= 3000 times /24 hours; 4. Symptoms of premature ventricular beats lasting for more than 1 week.
Exclusion criteria
Exclusion criteria: 1. Patients who are seriously ill,need to be treated with other antiarrhythmic drugs; 2. Acute coronary syndrome (patients with acute st-segment elevation myocardial infarction, acute non-st-segment elevation myocardial infarction and unstable angina); 3. The patients whose NYHA graded III, IV or left ejection fraction <40%; 4. Premature ventricular beats caused by other systemic diseases (such as anemia, hyperthyroidism, etc.), digitalis poisoning and electrolyte disorders; 5. Pregnant or lactating women, mentally illness; 6. Heart rate <60 beats /min; 7. Patients with severe primary diseases such as liver, kidney and hematopoietic system, in which the upper limit of ALT, AST and Cr 1.5 times more than the normal in the blood; 8. Performed cardiac PCI or bypass surgery in the recent 3 months; 9. Hypertension graded 3 or above, with unstable blood pressure controllment; 10. Patients treated with metoprolol tartrate tablets within 1 week; 11. Those who are allergic to the drug ingredients of the test or have an allergic constitution; 12. Participating in other clinical trials within 3 months prior to the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of 24-hour dynamic electrocardiogram; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of diurnal premature ventricular beat;The efficacy of 24-hour Holter;the score of SAS scale; | — |
Countries
China
Contacts
Public ContactMing Ren
Baokang Hospital of Tianjin University of TCM
Outcome results
None listed