Hemodialysis
Conditions
Interventions
1:phase I: low dose citrate anticoagulation, 3 times
phase II: normal dose citrate anticoagulation, 3 times.
2:phase I: normal dose citrate anticoagulation, 3 times
phase II: low dose citrate anticoagulation, 3 times.
Sponsors
Department of Nephrology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Sign the written informed consent form. 2) Patients between the ages of 18 and 75 are not limited to men and women. 3) Maintenance hemodialysis patients (dialysis over 3 months), dialysis 3 times a week, of which at least 2 times a week for general hemodialysis. 4) Patients with stable blood flow velocity during dialysis and greater than 180 mL/min. The blood flow velocity during the dialysis was stable and was greater than 180 mL/min. 5) There is a risk of bleeding and it is not possible to use heparin anticoagulation patients.
Exclusion criteria
Exclusion criteria: 1) Respiratory failure. 2) Liver dysfunction, serum ALT and AST are more than 2 times the upper limit of normal. 3) Patients with congenital heart disease, arrhythmia, heart failure and other serious cardiovascular diseases. 4) Patients who use other anticoagulant drugs at the same time (including heparin, low molecular weight heparin, direct anticoagulant preparation, warfarin, etc.). 5) Female patients who are pregnant, breast-feeding, or unwilling to take contraception. 6) Patients who have participated in other clinical trials within the first three months of enrollment. 7) The investigator judges that the patient's condition is not suitable for participation in this experimental study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Complete dialysis ratio;Complications;Coagulation grading; | — |
Countries
China
Contacts
Public ContactHong Daqing; Deng Fei
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Outcome results
None listed