amnestic mild cognitive impairment
Conditions
Interventions
Gold Standard:The result of PET imaging Aß test is used as gold standard
Index test:MBT 
distinguishes 
the 
optimal 
threshold 
and 
AUC 
for 
aMCI 
from 
controls
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria of case group: 1. Male and female aged between 55-85 years old; 2. Having primary school education and above; 3. meeting the core clinical standards of NIA-AA for aMCI; 4. CDR<=0.5; 5. the result of amyloid PET imaging is positive. The Inclusion criteria of health control group: 1. Male and female aged between 55-85 years old; 2. Having primary school education and above; 3. No cognitive decline; 4. CDR=0; 5. the result of amyloid PET imaging is negative.
Exclusion criteria
Exclusion criteria: The exclusion criteria of case group: 1. Currently suffering from mental disorders such as organic mental disorders, schizophrenia, schizoaffective psychosis, delusional mental disorders, undetermined psychotic disorders, bipolar disorder, substance abuse (including alcohol, psychoactive substances, etc.); 2. Currently suffering from other systemic or brain diseases that can lead to cognitive decline, such as cerebrovascular disease, Parkinson's disease, normal pressure hydrocephalus, hyperthyroidism or hypothyroidism, serum folic acid, low vitamin B12 levels, etc.; 3. Clinical diagnosis of dementia. The exclusion criteria of health control group: 1. Currently suffering from severe unstable nervous system diseases such as cerebrovascular disease, Parkinson's disease, normal pressure hydrocephalus, etc.; 2. Currently suffering from serious and unstable medical diseases such as heart disease, respiratory disease, kidney disease, digestive system disease, thyroid disease, serum folic acid, and low vitamin B12 levels; 3. Currently suffering from mental disorders such as organic mental disorders, schizophrenia, schizoaffective psychosis, delusional mental disorders, undetermined psychotic disorders, bipolar disorder, substance abuse (including alcohol, psychoactive substances, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the optimal threshold and AUC for aMCI from normal controls; | — |
Countries
China
Contacts
Public ContactTao Li
Peking University Sixth Hospital
Outcome results
None listed