Sarcoma
Conditions
Interventions
Case series:An+EPI?An
Sponsors
Zhongshan Hospital ,Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18 to 75 years previously untreated STS patients who lost the chance of radical surgery; 2. Histologically proven STS, but Ewing sarcoma, RMS, WDDLP, WDLPS, ASPS, EMC, CCS were excluded; 3. For recurrence cases, no previous anthracycline-based therapy; 4. Measurable disease according to the RECIST1.1; 5. ECOG/PS 0-1; 6. Estimated survive >=12 weeks. 7. Sufficient bone marrow and organ function; 8. Maintain contraception during the study.
Exclusion criteria
Exclusion criteria: 1. Prior palliative chemotherapy, targeted or other therapy for the advanced STS; 2. Central nervous system metastases; 3. Systemic hormone use, inhalation is not counted; 4. Other malignant cancer in recent 5 years; 5. Serious DM or middle-high organ function impairment; 6. CVD need to interfere or uncontrollable hypertension; 7. Risk of bleeding, obstruction or perforation; 8. Risk of thrombosis or history of thrombosis; 9. Uncontrolled infections; HIV positive; Immunodeficiency; 10. Heart-based disease, including CVD, Myocardial infarction, heart dysfunction, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFR (12weeks & 24 weeks); | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;PFS;DCR;OS;Safety (according to CTCAE1.1); | — |
Countries
China
Contacts
Public ContactZhou Yuhong
Zhongshan Hospital, Fudan University
Outcome results
None listed