High risk factors for cardiovascular disease
Conditions
Interventions
Experimental group:Sea buckthorn powder
Control group:Seabuckthorn powder placebo
Sponsors
Fuwai Hospital Chinese Academy of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Fasting blood glucose>=6.1mmol /L, or 2h blood glucose>=7.8mmol/L after glucose load and (or) already diagnosed with diabetes; 3. Hypertension: blood pressure >=130/85 mmHg or confirmed as hypertension and treated; 4. Fasting TG >=1.70mmol/L and/or fasting HDL-C=90 cm, female >=85 cm; 6. Hypersensitive c-reactive protein between 2-5mg/L; 7. Sign an informed consent form. Note: meet any three or more items of 2 to 5 could be eligible.
Exclusion criteria
Exclusion criteria: 1. BMI>45kg/m2; 2. Weight changes of +/-3kg or more in the past 2 weeks; 3. Nephropathy range proteinuria>3g/d; 4. History of malignant tumor; 5. Bariatric surgery history; 6. Taking weight loss drugs for more than 6 months; 7. More than 1.5 times normal value of thyroid stimulating hormone (TSH); 8. Liver dysfunction, ALT or AST > 3 times normal or combined with cirrhosis; 9. Unexplained creatine kinase (CK) > 3 times normal, or known muscle disease; 10. Renal insufficiency, male serum creatinine>2.5mg/dl (221umol/L) female serum creatinine >2.0 mg/dl (177umol/L); 11. Infection, fever, trauma, burns, history of surgery in the past 1 month; 12. Active rheumatic immune disease, tuberculosis patients; 13. Antibiotics or detoxification Chinese medicine practitioners are applying; 14. Participated in other clinical trials in the past month; 15. Unwilling to cooperateunwilling to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Four blood lipids;blood sugar;Liver and kidney function;Electrolyte; | — |
Countries
China
Contacts
Public ContactXue Feng
Fuwai Hospital Chinese Academy of Medical Sciences (CAMS)
Outcome results
None listed