Perioperative melatonin level changes in postmenopausal women with general anesthesia and postoperative anxiety and the effect of melatonin on postoperative anxiety in perimenopausal women

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024906

Enrollment

Unknown

Registered

2019-08-03

Start date

2019-07-31

Completion date

Unknown

Last updated

2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative anxiety in perimenopausal women

Interventions

Experimental group:Oral melatonin 6 mg at 8 pm 1 day before surgery and half an hour before surgery

control group:None

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Choose our hospital from July 2019 to April 2020; 2. menopausal women; 3. Aged 40-60 years old; 4. ASAI ~ III.

Exclusion criteria

Exclusion criteria: 1. Unstable mental illness, abnormal electrocardiogram, high blood pressure and severe heart disease; 2. Preoperative diagnosis of patients with history of depression; 3. STAI, HADS, BAI (excluding baseline values); 4. Lost or refused to accept written informed consent.

Design outcomes

Primary

Measure	Time frame
The amount of melatonin in saliva;Anxiety score;	—

Secondary

Measure	Time frame
sleeping time;NRS;MMSE;	—

Countries

China

Contacts

Public ContactPing Zhao

Department of Anesthesiology, Shengjing Hospital, China Medical University

zhaop@sj-hospital.org+86 18940258971

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026