Chronic Kidney Disease
Conditions
Interventions
Case Series:N/A
Sponsors
TongJi Medical College Of Huazhong University Of Science & Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: patients with an estimated glomerular filtration rate (eGFR) lower than 15 ml/min/1.73 m2, receiving CAPD treatment longer than 3 months, aged between 18 and 65 years and able to provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients will be excluded if they meet any of the following criteria: with a diagnosis of diabetes mellitus; 2. consumed antibiotic therapy within 1 month of study commencement; 3. receiving/or have received radiation to the bowel or large bowel resection; medically diagnosed irritable bowel syndrome, Crohns disease or ulcerative colitis; 4. severely malnourished (Subjective Global Assessment > 15); 5. having had a clinically significant change to their immunosuppressant dose within 6 months (determined by the medical team).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cadiovascular and cerebrovascular events;technical survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| kidney function;dietary protein and energy intake;Serum albumin, prealbumin,the subjective global assessment score;serum including hs-CRP, interleukin6 (IL-6) and tumor necrosis factor-a (TNF-alpha);serum lipid profile;serum glucose;blood pressure;Indoxyl sulfate in serum, dialysate, urine and fecal samples;p-cresyl sulfate in serum, dialysate, urine and fecal samples; | — |
Countries
China
Contacts
Public ContactXuezhi Zuo
Tongji Hospital, Tongji Medical College, Huazhong University Science and Technology
Outcome results
None listed