allergic diseases, atopic dermatitis, asthma, allergic rhinitis
Conditions
Interventions
Experimental group:Preventive Antenatal Education (PAE)
Control group:Standard Antenatal Education (SAE)
Sponsors
Beijing Children's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Enlisted in the birth registry of Beijing Daxing District People's Hospital-Capital Medical University Daxing Teaching Hospital and will birth at the aformentioned location; 2. Women aged between 18 and 40 years; 3. Less than 12 gestional week when recruited as measured by last menstrual period; 4. Residents of Huangcun, Daxing and intend to remain residing in Huangcun, Daxing for at least two years postpartumly; 5. Written consent form. 6. Able to communicate in written and spoken Chinese.
Exclusion criteria
Exclusion criteria: 1. Still birth; 2. Late abortion; 3. Rare comorbidities including tumor, birth defects (congenital heart disease, diaphragmatic hernia, Hirschsprung's disease), intrahepatic cholestasis of pregnancy, acute fatty liver disease, complete placenta previa, eclampsia,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| atopic dermatitis incidence of the children;atopic derma disease severity (SCORAD) of the children;Infant dermatitis life quality index;allergic disease knowledge and attitude of the parents;infantile wheezing incidence;allergic rhinitis incidence of the children;atopic dermatitis flares of the children;disease (atopic dermatitis) free days of the children; | — |
Secondary
| Measure | Time frame |
|---|---|
| prevalence of food allergy of the children;changes in skin microbiome of the children;serum/plasma IgE and other inflammatory cytokines of the children; | — |
Countries
China
Contacts
Public ContactLin Ma
Beijing Children's Hospital
Outcome results
None listed